![hippocampus stereology hippocampus stereology](https://www.jneurosci.org/content/jneuro/21/10/3503/F2.large.jpg)
![hippocampus stereology hippocampus stereology](https://i.pinimg.com/600x315/9d/60/d1/9d60d102737d9dbe060ea9b1994b8c3e.jpg)
In the amygdala, significant reduction of neuronal density was limited to the lateral nucleus (by 12%). In the group of individuals with autism, the total number and numerical density of Purkinje cells in the cerebellum were reduced by 25% and 24%, respectively. The study revealed that significant differences between the group of subjects with autism and control groups are limited to a few brain regions, including the cerebellum and some striatum and amygdala subdivisions.
![hippocampus stereology hippocampus stereology](https://www.researchgate.net/publication/326183781/figure/fig2/AS:644659248386059@1530710150728/A-Microglial-activation-measured-by-Iba1-immunoreactivity-optical-density-in_Q320.jpg)
The volume of cytoarchitectonic subdivisions, neuronal numerical density, and total number of neurons per region of interest were determined in 14 subjects with autism and 14 age-matched controls by using unbiased stereological methods. A total of 38 brain cytoarchitectonic subdivisions, representing subcortical and cortical structures, cerebellum, and brainstem, were examined in 4- to 60-year-old subjects diagnosed with autism and control subjects (a) to detect a global pattern of developmental abnormalities and (b) to establish whether the function of developmentally modified structures matches the behavioral alterations that are diagnostic for autism.